Case-Control Association Testing
deCODE established its reputation in human genetics largely through case-control studies. We have discovered and published hundreds of major genetic variants linked to complex phenotypes through very studies of this type, and we put this expertise at your service. To see a list of our publications, some of which may give you a concrete idea of what we have done in a disease or trait of interest to you, click here.
For your study, just like we do for ours, we will calculate the OR for each SNP allele or haplotype assuming the multiplicative model; that is, assuming that the risk of a homozyogous carrier relative to a noncarrier is the square of the risk of a heterozygous carrier relative to a noncarrier. We will also present allelic frequencies and OR for each of the markers.
We calculate the associated P values using standard logistic regression. P-values are be scaled by the method of genomic control, with the inflation factor obtained by comparing observed median of all chi-square test statistics to the value predicted by theory (Devlin et al 2004). Both unadjusted and adjusted p-values will be provided.
For more information, please contact services@decode.com
