Valgerdur Steinthorsdottir. Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination. Summary data (1.3GB)
The UK Biobank Whole-Genome Sequencing Consortium. Whole-genome sequencing of half-million UK Biobank participants. Summary Data (14GB)
Bjornsdottir et al. Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura. Summary Data (9.1 GB)
Kristmundsdottir, S et al. Sequence variants affecting the genome-wide rate of germline microsatellite mutations. Read me file (1 KB). Summary data (4.4 GB).
Kristjansson, R et al. Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria. Readme file (1 KB). Summary data (673 MB).
Nawaz MS, Einarsson G, et.al. Thirty novel sequence variants impacting human intracranial volume. Summary data (891 MB)
Ghouse J, Tragante V, et al. Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism. Read me file (1 KB), US (280 MB), DK (200 MB), IS (300 MB), meta (220 MB).
Henkel, et al. Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement. Read me file (2 KB). Osteoarthritis hip joint replacement (660 MB), Osteoarthritis hip without hip joint replacement (660 MB), Osteoarthritis knee joint replacement (660 MB), Osteoarthritis knee without knee joint replacement (660 MB).
Olafsdottir, T.A and Bjarnadottir, K. HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2. Read me file (1 KB), Summary data (148 KB), Auto Gater (40 KB).
Halldorsson, B.V. et al. The sequences of 150,119 genomes in the UK biobank. Summary data.
Saevarsdottir S. et al. Multi-omics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset. Read me file (1 KB). Summary data (1 GB). Seronegative (1 GB). Seropositive (1 GB).
Mikaelsdottir EK, et al. Genetic variants associated with platelet count are predictive of human disease and physiological markers. Read me file (1 KB), PRS weights Iceland (5 MB), PRS weights UKB (5 MB), Meta (980 MB).
Dowsett J. et al. Eleven Genomic Loci Affect Plasma Levels of Chronic Inflammation Marker Soluble Urokinase-type Plasminogen Activator Receptor. Communications Biology, 2021. Read me file (1 KB). Summary data (900 MB).
Juliusdottir, T., et al. Distinction between the effects of parental and fetal genomes on fetal growth. Read me file (1 KB). Birthlength.gz (570 MB), Birthweight.gz (620 MB), Birthweight_offspring_mothers.gz (610 MB), Birthweight_offspring_fathers.gz (620 MB), Poinderal_index.gz (620 MB).
Bell S, et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Read me file (2 KB). Ferritin (450 MB), serum iron (450 MB), TIBC (450 MB), TSAT (450 MB).
Olafsdottir, T. et al. Loss-of-Function Variants in the Tumor Suppressor Gene PTPN14 confer increased Cancer Risk. Summary data (200 KB)
Gisladottir, R., et al. Sequence variants in TAAR5 and other loci affect human odor perception and naming. Summary data (8 GB).
Olafsdottir T, et al. Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank. Summary data (700 MB).
Oskarsson, et al. Predicted loss and gain of function mutations in ACO1 are associated with erythropoiesis. Summary data (700 MB).
Saevarsdottir, et al. FLT3 stop mutation raises FLT3 ligand and autoimmune thyroid disease risk. Summary data (850 MB).
Olafsdottir T.A., et al, Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis. Summary data (570 MB).
Liyanarachchi, et al. Assessing thyroid cancer risk using polygenic risk scores. Summary data (13 MB).
Norland, K. et al. Sequence variants with large effects on cardiac electrophysiology and disease. Summary data (47 GB).
Styrkarsdottir, U et al. GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. Summary data.
Bjornsdottir, G. et al. A PRPH splice-donor variant associates with reduced sural nerve amplitude and risk of peripheral neuropathy. Summary data.