Rare loss-of-function variants in HECTD2 and AKAP11 confer a risk of bipolar disorder

Mar 25, 2025 | NEWS

Scientists at deCODE genetics, a subsidiary of Amgen, reveal today in Nature Genetics, associations between rare loss-of-function variants in two genes and bipolar disorder.Bipolar disorder is characterized by extreme mood swings, bouts of mania or hypomania, and...

Discovery of cancer risk associations for six novel genes

Oct 29, 2024 | NEWS

Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title “Gene-based burden tests of rare germline...

Discovery of a rare genotype causing primary ovarian insufficiency 

Aug 27, 2024 | NEWS

Scientists at deCODE genetics and collaborators, have identified a sequence variant in the CCDC201 gene that when inherited from both parents homozygous causes menopause on average nine years earlier.  Kari Stefansson, Patrick Sulem and Asmundur Oddsson authors...

Variants in the genome affect DNA methylation

Jul 24, 2024 | deCODE genetics, NEWS

A new study by scientists at deCODE Genetics, a subsidiary of Amgen, shows that sequence variants drive the correlation between DNA methylation and gene expression. The same variants are linked to various diseases as well as other human traits. Kari Stefansson, senior...

Epidemiology and Genetics of Clonal Hematopoiesis, a Premalignant Hematopoietic Stem Cell Condition

Nov 6, 2023 | NEWS

A comprehensive new study from deCODE genetics, a subsidiary of Amgen, published today in Nature Genetics, provides insights into the epidemiology and somatic and germline genetics of clonal hematopoiesis. Whole genome sequence data from Iceland and the UK Biobank,...